Keratoconus in Hormonal Flux  - Summary - MDSpire

Keratoconus in Hormonal Flux 

Is it time to rethink the importance of hormonal changes on keratoconus pathology?

  • February 12, 2026

  • 3 min

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Objective:

To explore the relationship between hormonal fluctuations and the onset or progression of keratoconus (KCN), and to propose a screening approach for vulnerable groups.

Approach:
    Key Findings:
    • 26 studies included, with 4,201 participants, showing a link between hormonal shifts and KCN onset or worsening.
    • Pregnancy identified as the most common endogenous trigger for KCN.
    • Elevated DHEAS consistently reported across studies measuring it, indicating a systemic component to KCN risk.
    Interpretation:

    The findings suggest that hormonal influences, particularly during significant fluctuations, play a critical role in KCN pathology and should be considered in clinical management.

    Limitations:
    • Evidence is largely observational, which may limit causal inferences.
    • Variability in methodologies and diagnostic criteria across studies.
    Conclusion:

    Integrating hormonal history into keratoconus risk assessment could enhance screening and management strategies, particularly during periods of hormonal change.

Original Source(s)

Keratoconus in Hormonal Flux 

  • February 12, 2026

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