Keratoconus in Hormonal Flux

Is it time to rethink the importance of hormonal changes on keratoconus pathology?

February 12, 2026
3 min

The Ophthalmologist

Objective:

To explore the relationship between hormonal fluctuations and the onset or progression of keratoconus (KCN), and to propose a screening approach for vulnerable groups.

Approach:

Key Findings:

26 studies included, with 4,201 participants, showing a link between hormonal shifts and KCN onset or worsening.
Pregnancy identified as the most common endogenous trigger for KCN.
Elevated DHEAS consistently reported across studies measuring it, indicating a systemic component to KCN risk.

Interpretation:

The findings suggest that hormonal influences, particularly during significant fluctuations, play a critical role in KCN pathology and should be considered in clinical management.

Limitations:

Evidence is largely observational, which may limit causal inferences.
Variability in methodologies and diagnostic criteria across studies.

Conclusion:

Integrating hormonal history into keratoconus risk assessment could enhance screening and management strategies, particularly during periods of hormonal change.

Keratoconus in Hormonal Flux

Objective:

Approach:

Key Findings:

Interpretation:

Limitations:

Conclusion:

Original Source(s)

Keratoconus in Hormonal Flux

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