Murray law-based quantitative flow ratio versus invasive fractional flow reserve in the left anterior descending coronary artery: impact of hydrostatic pressure correction and clinical implications - Summary - MDSpire

Murray law-based quantitative flow ratio versus invasive fractional flow reserve in the left anterior descending coronary artery: impact of hydrostatic pressure correction and clinical implications

  • By

  • András Ágoston

  • Ádám Piricsi

  • Bettina Szekeres

  • Mátyás Magyari

  • Balázs Tar

  • Gábor T. Szabó

  • Csaba A. Dézsi

  • Zsolt Piroth

  • Zoltán Ruzsa

  • Gábor G. Tóth

  • Shengxian Tu

  • Zsolt Kőszegi

  • June 17, 2026

  • 0 min

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Objective:

To investigate whether correcting invasive FFR for hydrostatic pressure error improves its agreement with QFR in the left anterior descending artery (LAD) lesions.

Approach:
    Key Findings:
    • Hydrostatic correction increased the mean FFR from 0.78 ± 0.11 to 0.81 ± 0.10 (p < 0.0001).
    • The mean μQFR was 0.81 ± 0.10, matching the hydrostatic pressure-corrected FFR.
    • Pearson correlation between μQFR and FFR was high (r = 0.95, p < 0.0001) both before and after correction.
    • Bland–Altman analysis showed that correcting the hydrostatic error eliminated the small bias between FFR and μQFR.
    Interpretation:

    Limitations:
    • The study was limited to a single center and a small sample size of 33 lesions.
    • Only LAD lesions were included, which may limit the generalizability of the findings.
    Conclusion:

Original Source(s)

Murray law-based quantitative flow ratio versus invasive fractional flow reserve in the left anterior descending coronary artery: impact of hydrostatic pressure correction and clinical implications

  • by András Ágoston, Ádám Piricsi, Bettina Szekeres, Mátyás Magyari, Balázs Tar, Gábor T. Szabó, Csaba A. Dézsi, Zsolt Piroth, Zoltán Ruzsa, Gábor G. Tóth, Shengxian Tu, Zsolt Kőszegi

  • June 17, 2026

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