Psilocybin for Cocaine Use: Signal or Noise? - Summary - MDSpire
From the Journals

Psilocybin for Cocaine Use: Signal or Noise?

Pilot randomized study suggests possible benefit, but blinding concerns and limited generalizability complicate interpretation

  • By

  • Kathryn Wighton

  • May 7, 2026

  • 6 min

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A randomized clinical trial published in JAMA Network Open examined the efficacy of psilocybin in treating cocaine use disorder by comparing it with an active placebo. The study involved 40 patients receiving psilocybin alongside intensive psychotherapy, leading to more cocaine-abstinent days and a lower risk of relapse. However, the preliminary findings are complicated by methodological limitations, including significant blinding issues and a small sample size. Experts caution against overinterpreting results, emphasizing the need for further research amidst current addiction treatment challenges.

Original Source(s)

Psilocybin for Cocaine Use: Signal or Noise?

  • by Kathryn Wighton

  • May 7, 2026

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