To summarize the dual roles of mesenchymal stem/stromal cells (MSCs) in tumor progression and explore engineering strategies to enhance their therapeutic potential for cancer treatment.
Key Findings:
MSCs can promote tumor growth through mechanisms such as angiogenesis, immune suppression, and therapy resistance.
MSCs can also exert antitumor effects under certain conditions, highlighting their dual roles.
Engineering MSCs may enhance their ability to deliver targeted therapies effectively.
Interpretation:
Limitations:
Challenges remain in harnessing MSCs for effective antitumor therapy.
Further optimization of MSC-based strategies is necessary for clinical application.
