To identify the risk factors and evaluate the predictive performance for adjacent vertebral fracture (AVF) after Percutaneous vertebroplasty (PVP), highlighting their clinical significance.
Key Findings:
AVF group was significantly older (76.4 vs. 72.6 years, P < 0.001).
Lower BMD T-scores in AVF group (-3.1 vs. -2.4, P < 0.001).
Lower BMI in AVF group (22.2 vs. 24.8 kg/m2, P < 0.001).
Advanced age (OR = 1.045, 95% CI: 1.018–1.074) and low BMD (OR = 2.85 per SD decrease, 95% CI: 2.12–3.82) were independent risk factors.
Combined prediction model achieved an AUC of 0.706.
Interpretation:
Advanced age and low BMD are significant independent risk factors for AVF post-PVP, with a combined model providing moderate predictive accuracy for risk stratification.
Limitations:
Predictive value of individual indicators is limited (AUC < 0.7), which may affect clinical applicability.
Study focused on a single institution, potentially limiting generalizability to broader populations.
BMD measurement limited to lumbar spine, not considering femoral neck or hip, which may overlook other risk factors.
Conclusion:
Advanced age and low BMD are critical factors for AVF risk after PVP, emphasizing the need for systemic osteoporosis management in prevention strategies to improve patient outcomes.
