To characterize the evolution of CMR and clinical findings in a pediatric cohort with COVID-19-related myocarditis, highlighting the significance of early, mid, and long-term imaging changes.
Key Findings:
21 patients with a mean age of 13.1 years; 57% male. Acute myocarditis confirmed in 38% of patients meeting Lake Louise criteria. EGE present in 77%, 83%, and 80% of early, mid, and late CMRs respectively. Abnormal T2 weighted ratio present in 15%, 8%, and 0% of early, mid, and late CMRs respectively. LGE present in 46%, 25%, and 0% of early, mid, and late CMRs respectively. No patients exhibited regional wall motion abnormalities or coronary artery involvement. These findings suggest a concerning trend in CMR abnormalities over time.
Interpretation:
The study indicates a high rate of functional recovery in pediatric patients with COVID-19-related myocarditis, with persistent CMR abnormalities observed in early and mid-term follow-ups, raising questions about long-term cardiac health.
Limitations:
Small sample size of 21 patients. Single-center study may limit generalizability and introduce biases. Lack of long-term follow-up data beyond one year.
Conclusion:
The findings suggest that while acute CMR findings are favorable, further research is needed to understand the implications of persistent CMR abnormalities and their potential long-term effects on pediatric cardiac health.
