The correlation between the atherogenic index of plasma and aortic valve calcification in the general population: a retrospective observational cohort study - Summary - MDSpire
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The correlation between the atherogenic index of plasma and aortic valve calcification in the general population: a retrospective observational cohort study
To explore the correlation between atherogenic index of plasma (AIP) and the risk of aortic valve calcification (AVC), highlighting its significance in cardiovascular health.
Key Findings:
Each 1-unit increase in AIP was associated with a 146.0% higher risk of AVC (OR = 2.460, 95% CI 1.525–3.969).
Risk of AVC increased across AIP quartiles: Q2 (1.623-fold, 95% CI), Q3 (2.405-fold, 95% CI), Q4 (2.319-fold, 95% CI) compared to Q1.
Higher AIP levels were significantly associated with increased AVC risk across most subgroups.
ROC curve analysis indicated AIP had moderate diagnostic value for AVC risk (AUC = 0.760, 95% CI).
Interpretation:
Higher levels of AIP are significantly associated with an increased risk of AVC, indicating that AIP holds important clinical value as an associative biomarker for AVC, with potential implications for patient management.
Limitations:
Conclusion:
The study suggests that AIP may provide unique, non-redundant information for AVC risk assessment, warranting further research into its clinical applications.
