J-shaped relationship between creatinine levels and the risk of three major adverse events in patients after percutaneous coronary intervention - Summary - MDSpire
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J-shaped relationship between creatinine levels and the risk of three major adverse events in patients after percutaneous coronary intervention
To evaluate the correlation between creatinine levels and the risk of major adverse cardiovascular events (MACE), non-adverse cardiovascular events (NACE), and major adverse cardiac and cerebrovascular events (MACCE) in patients after PCI, and to identify a potential correlation threshold.
Key Findings:
25.7% of patients experienced adverse events post-PCI.
A J-shaped relationship was found between creatinine levels and the likelihood of adverse events (nonlinear P < 0.05).
The inflection point for creatinine levels was identified at 110 μmol/L.
Patients with creatinine levels below 110 μmol/L had a 15.5% increase in MACE risk (95% CI: 1.006-1.327), a 15.6% increase in NACE risk (95% CI: 1.004-1.330), and a 16.1% increase in MACCE risk (95% CI: 1.015-1.329).
Interpretation:
Creatinine levels exhibit a non-linear relationship with the risk of adverse events post-PCI, indicating that both low and high levels can be associated with increased risk, which has important implications for patient management.
Limitations:
Retrospective design may introduce selection bias.
Data collection relied on medical records and patient interviews, which may affect accuracy.
Findings may not be generalizable to populations outside the study cohort.
Conclusion:
The study identifies a J-shaped correlation between creatinine levels and adverse events post-PCI, with 110 μmol/L as a critical threshold for risk stratification.
