Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial - Summary - MDSpire

Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial

  • By

  • Christian S. Hendershot

  • Michael P. Bremmer

  • Michael B. Paladino

  • Georgios Kostantinis

  • Thomas A. Gilmore

  • Neil R. Sullivan

  • Amanda C. Tow

  • Mark A. Prince

  • Sarah S. Dermody

  • Robyn Jordan

  • Sherry A. McKee

  • Paul J. Fletcher

  • Eric D. Claus

  • Klara R. Klein

  • May 26, 2026

  • 0 min

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Objective:

To evaluate the effects of semaglutide monotherapy on smoking-related outcomes in non-treatment-seeking adults who smoke, emphasizing the unique population.

Key Findings:
  • Semaglutide was administered weekly for 9 weeks to evaluate its impact on smoking behavior, with specific outcomes measured.
  • Participants underwent laboratory smoking sessions to assess smoking reinstatement and self-administration, with results indicating significant changes.
Interpretation:

The study aims to explore the potential of semaglutide as a therapeutic option for smoking cessation in individuals not actively seeking to quit, highlighting the importance of these findings.

Limitations:
  • The trial duration limited the use of higher doses of semaglutide, which may affect the generalizability of the results.
  • Participants were not provided with other smoking cessation interventions, potentially limiting the effectiveness of semaglutide alone.
Conclusion:

The study investigates the effects of semaglutide on smoking outcomes, contributing to the understanding of potential new therapies for smoking cessation, with implications for future research.

Original Source(s)

Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial

  • by Christian S. Hendershot, Michael P. Bremmer, Michael B. Paladino, Georgios Kostantinis, Thomas A. Gilmore, Neil R. Sullivan, Amanda C. Tow, Mark A. Prince, Sarah S. Dermody, Robyn Jordan, Sherry A. McKee, Paul J. Fletcher, Eric D. Claus, Klara R. Klein

  • May 26, 2026

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