Tailored Dosimetry Improves Treatment Outcomes in Hepatocellular Carcinoma with Yttrium-90 Resin Microsphere Radioembolization - Summary - MDSpire

Tailored Dosimetry Improves Treatment Outcomes in Hepatocellular Carcinoma with Yttrium-90 Resin Microsphere Radioembolization

  • By

  • Ettore di Gaeta

  • Makoto Taninokuchi Tomassoni

  • Francesca Calabrese

  • Giovanni Matassa

  • Annarita Savi

  • Carla Canevari

  • Patrizia Magnani

  • Giovanna Pepe

  • Stephanie Steidler

  • Francesca Ratti

  • Federica Cipriani

  • Margherita Rimini

  • Andrea Casadei-Gardini

  • Lorenzo Braccischi

  • Maria Adriana Cocozza

  • Lidia Strigari

  • Giuseppe Della Gala

  • Arber Golemi

  • Elisa Lodi Rizzini

  • Stefano Fanti

  • Matteo Cescon

  • Matteo Serenari

  • Fabio Piscaglia

  • Maria Cristina Morelli

  • Arturo Chiti

  • Cristina Mosconi

  • Francesco De Cobelli

  • April 28, 2026

  • 0 min

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Objective:

To evaluate the efficacy of a threshold dose (Dmean) in patients with early to advanced-stage HCC treated with resin microspheres, focusing on overall response rate (ORR) at 3 months in a specific patient population.

Key Findings:
  • Personalized dosimetry improved overall survival (OS) and objective response rate (ORR), indicating significant clinical implications.
  • A threshold dose of > 120 Gy was targeted for tumor absorption while limiting normal liver and lung doses.
  • Radiological response was assessed using modified Response Evaluation Criteria in Solid Tumors (mRECIST) at 3 months post-TARE.
Interpretation:

The study supports the use of tailored dosimetry in TARE for HCC, indicating that personalized treatment planning can enhance therapeutic outcomes.

Limitations:
  • Retrospective design may introduce selection bias, potentially affecting the reliability of the findings.
  • Limited generalizability due to the specific patient population and treatment protocols, which may not apply to broader HCC cases.
Conclusion:

Tailored dosimetry in TARE for HCC patients leads to improved treatment outcomes, emphasizing the importance of personalized treatment approaches.

Original Source(s)

Tailored Dosimetry Improves Treatment Outcomes in Hepatocellular Carcinoma with Yttrium-90 Resin Microsphere Radioembolization

  • by Ettore di Gaeta, Makoto Taninokuchi Tomassoni, Francesca Calabrese, Giovanni Matassa, Annarita Savi, Carla Canevari, Patrizia Magnani, Giovanna Pepe, Stephanie Steidler, Francesca Ratti, Federica Cipriani, Margherita Rimini, Andrea Casadei-Gardini, Lorenzo Braccischi, Maria Adriana Cocozza, Lidia Strigari, Giuseppe Della Gala, Arber Golemi, Elisa Lodi Rizzini, Stefano Fanti, Matteo Cescon, Matteo Serenari, Fabio Piscaglia, Maria Cristina Morelli, Arturo Chiti, Cristina Mosconi, Francesco De Cobelli

  • April 28, 2026

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