Objective:

To preliminarily identify risk factors for post-cESD stricture, focusing on steroid-based prophylaxis.

Approach:

Key Findings:

• A longitudinal length of circumferential involvement exceeding 50 mm was identified as an independent risk factor for post-cESD stricture (OR 9.10, 95% CI 2.27–33.30, P = 0.002).
• SSPS demonstrated a significant protective effect compared to CST (OR 0.22, 95% CI 0.05–0.91, P = 0.036).
• Extensive circumferential involvement was associated with stricture in the CST group but not in the SSPS group.

Interpretation:

The findings suggest that a longitudinal length of circumferential involvement over 50 mm is a significant predictor of post-cESD stricture, and SSPS may offer better protection than CST.

Limitations:

• The subgroup analysis was limited by small sample size, which may affect the reliability of the findings.
• Total steroid exposure was not calculated.

Conclusion:

These findings are preliminary and require validation in larger prospective studies.

Attribution Notice

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