Defibrotide for prophylaxis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) in pediatric high-risk patients: consensus guidelines from the European Society for Blood and Marrow Transplantation (EBMT) - Summary - MDSpire
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Guidelines from the European Society for Blood and Marrow Transplantation (EBMT) on the Use of Defibrotide to Prevent Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease in High-Risk Pediatric Patients

  • By

  • Selim Corbacioglu

  • Rajinder Bajwa

  • Ali Bülent Antmen

  • Adriana Balduzzi

  • Jaap Jan Boelens

  • Francesca Bonifazi

  • Simone Cesaro

  • Fabio Ciceri

  • Antonio Colecchia

  • Fiona Dignan

  • Katharina Kleinschmidt

  • Kris M. Mahadeo

  • Antonio Pagliuca

  • Petr Sedlacek

  • Peter J. Shaw

  • Jerry Stein

  • Zofia Szmit

  • Francesco Tambaro

  • Elif Ince

  • Marta Verna

  • Akif Yesilipek

  • Marco Zecca

  • Paul G. Richardson

  • Mohamad Mohty

  • Krzysztof Kalwak

  • January 13, 2026

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Objective:

Emphasize the importance of addressing pediatric-specific challenges in SOS/VOD.

Key Findings:
  • Include more context on the implications of anicteric SOS/VOD.
Interpretation:

Strengthen the connection to the implications of the findings.

Limitations:
  • Specify which studies are retrospective to clarify potential biases.
Conclusion:

Reiterate the significance of early intervention and the role of defibrotide.

Original Source(s)

Defibrotide for prophylaxis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) in pediatric high-risk patients: consensus guidelines from the European Society for Blood and Marrow Transplantation (EBMT)

  • by Selim Corbacioglu, Rajinder Bajwa, Ali Bülent Antmen, Adriana Balduzzi, Jaap Jan Boelens, Francesca Bonifazi, Simone Cesaro, Fabio Ciceri, Antonio Colecchia, Fiona Dignan, Katharina Kleinschmidt, Kris M. Mahadeo, Antonio Pagliuca, Petr Sedlacek, Peter J. Shaw, Jerry Stein, Zofia Szmit, Francesco Tambaro, Elif Ince, Marta Verna, Akif Yesilipek, Marco Zecca, Paul G. Richardson, Mohamad Mohty, Krzysztof Kalwak

  • January 13, 2026

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