Bacterial and Viral Coinfections in Adult Patients Hospitalized With COVID-19 Throughout the Pandemic: A Multinational Cohort Study in the EuCARE Project - Summary - MDSpire

Bacterial and Viral Coinfections in Adult Patients Hospitalized With COVID-19 Throughout the Pandemic: A Multinational Cohort Study in the EuCARE Project

  • By

  • Pontus Hedberg

  • Karol Serwin

  • Maria Francesca Greco

  • Joana P. V. Pereira

  • Dovile Juozapaite

  • Sara De Benedittis

  • Francesca Bai

  • Nadine Lübke

  • Tobias Wienemann

  • Iuri Fanti

  • Florian König

  • Nico Pfeifer

  • Rolf Kaiser

  • Maurizio Zazzi

  • Alessandro Cozzi-Lepri

  • Daniel Naumovas

  • Giulia Marchetti

  • Milosz Parczewski

  • Björn-Erik Ole Jensen

  • Francesca Incardona

  • Anders Sönnerborg

  • Pontus Nauclér

  • April 3, 2025

  • 0 min

Share

Objective:

To investigate the prevalence of bacterial and viral coinfections in adult COVID-19 patients during the wild type, Alpha, Delta, and Omicron variant periods and their association with in-hospital mortality.

Key Findings:
  • Coinfection rates were 2.6% (wild type), 2.0% (Alpha), 3.2% (Delta), and 7.9% (Omicron).
  • Omicron variant showed a significantly increased risk ratio of coinfection compared to pre-Omicron variants (1.88).
  • Patients with coinfections had a higher occurrence (19%) and adjusted risk (1.69) of in-hospital mortality compared to those without.
Interpretation:

Bacterial and viral coinfections were more prevalent during the Omicron period, and these coinfections were associated with an increased risk of in-hospital mortality.

Limitations:
  • The study may not fully represent all geographical regions due to limited data from certain hospitals, particularly in underrepresented areas.
  • Exclusion criteria may limit the generalizability of findings to all hospitalized COVID-19 patients, particularly those with multiple variants.
Conclusion:

The findings highlight the need for ongoing monitoring of coinfections in COVID-19 patients, particularly during the Omicron variant period, to inform clinical practices and antibiotic stewardship effectively.

Original Source(s)

Bacterial and Viral Coinfections in Adult Patients Hospitalized With COVID-19 Throughout the Pandemic: A Multinational Cohort Study in the EuCARE Project

  • by Pontus Hedberg, Karol Serwin, Maria Francesca Greco, Joana P. V. Pereira, Dovile Juozapaite, Sara De Benedittis, Francesca Bai, Nadine Lübke, Tobias Wienemann, Iuri Fanti, Florian König, Nico Pfeifer, Rolf Kaiser, Maurizio Zazzi, Alessandro Cozzi-Lepri, Daniel Naumovas, Giulia Marchetti, Milosz Parczewski, Björn-Erik Ole Jensen, Francesca Incardona, Anders Sönnerborg, Pontus Nauclér

  • April 3, 2025

Related Content

Assessing PEPFAR’s Economic and Educational Spillover Effects: An Update

Hantavirus Outbreak Revives COVID-Era False Health Claims — The Monitor

Stewardship Cuts Steroid Prescribing

Behaviorally informed peer comparison feedback was associated with a gradual decline in glucocorticoid prescribing