To enhance understanding of the diagnosis, imaging, and treatment of Alzheimer’s disease and related dementia (ADRD) for better screening and management in primary care and neurology settings, particularly in light of recent advancements.
Key Findings:
Dementia manifests as a severe cognitive impairment affecting daily functioning, with Alzheimer’s disease being the most common etiology and requiring tailored management strategies.
Incidence of dementia increases significantly with age, particularly after 85 years, necessitating age-specific screening protocols.
Risk factors for dementia include age, genetic predisposition (APOE4 allele), and demographic factors such as race and socioeconomic status, highlighting the need for equitable care approaches.
Interpretation:
The diagnosis and management of ADRD are evolving, particularly with advancements in imaging techniques and the introduction of blood-based biomarkers that enhance diagnostic accuracy and treatment monitoring.
Limitations:
The review may not encompass all recent developments in ADRD management, potentially limiting its applicability.
Potential biases in the selection of studies from the MEDLINE/PubMed database may affect the comprehensiveness of the findings.
Conclusion:
Understanding the complexities of dementia presentations and the importance of early diagnosis, especially in light of new treatment options, can significantly improve patient outcomes.
