Outcomes after using cerebral embolic protection devices during transcatheter aortic valve replacement: an updated meta-analysis - Summary - MDSpire

Outcomes after using cerebral embolic protection devices during transcatheter aortic valve replacement: an updated meta-analysis

  • By

  • Mohamed Saad Sayed

  • Amro K. AlQurm

  • Waleed Mohaned Rasheed

  • Kenda Yousef Abedal- Kareem

  • Saeb M. Albsoul

  • Sara K. AlQurm

  • Shatha M. Ramadneh

  • Jude N. Haddad

  • Obadah Aqtash

  • Tulio Caldonazo

  • May 18, 2026

  • 0 min

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Objective:

To systematically evaluate the efficacy and safety of cerebral embolic protection (CEP) devices during transcatheter aortic valve replacement (TAVR), addressing the uncertainty surrounding their clinical benefits, using evidence from randomized controlled trials (RCTs).

Key Findings:
  • CEP devices did not significantly reduce the overall risk of all-cause stroke (RR 0.92; 95% CI 0.73–1.14; p = 0.43) across nine RCTs comprising 11,696 patients.
Interpretation:

The use of CEP devices during TAVR does not confer a significant reduction in stroke risk compared to controls, suggesting limited clinical benefit and highlighting the need for further investigation.

Limitations:
  • The analysis was restricted to RCTs, which may limit generalizability, and potential publication bias could affect the results.
Conclusion:

CEP devices do not reduce the risk of stroke in patients undergoing TAVR compared to no protection, indicating a need for further research to explore their efficacy.

Original Source(s)

Outcomes after using cerebral embolic protection devices during transcatheter aortic valve replacement: an updated meta-analysis

  • by Mohamed Saad Sayed, Amro K. AlQurm, Waleed Mohaned Rasheed, Kenda Yousef Abedal- Kareem, Saeb M. Albsoul, Sara K. AlQurm, Shatha M. Ramadneh, Jude N. Haddad, Obadah Aqtash, Tulio Caldonazo

  • May 18, 2026

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