High progesterone may be tied to syringoma

Elevated levels occurred in 29% of women with the condition compared with 6% of controls in a cross-sectional study.

To assess the relationship between serum progesterone levels and the presence of syringoma in women.

Study Design: A single-center observational study was conducted with 70 women, including 35 patients with syringoma and 35 controls, aged 18 years or older with regular menstrual cycles.
Data Collection: Blood samples were collected during the luteal phase to measure serum progesterone levels using an enzyme-linked immunosorbent assay.
Diagnosis: Syringoma was diagnosed through clinical and dermoscopic examination, with histopathologic confirmation reserved for atypical cases.

High serum progesterone was found in 29% of patients with syringoma compared to 6% of controls.
Patients with syringoma had 6.6 times the odds of having high serum progesterone compared to controls.
Localized syringoma was the most common form, affecting primarily the periorbital region.

The study's single-center, cross-sectional design limits causal inference.
Blood sampling was not consistently timed to a specific cycle day.
Diagnosis was based on clinical criteria without routine histopathologic confirmation.
Potential confounders were not adjusted for in multivariable analyses.