Acute Kidney Injury After Pediatric Heart Transplant: The Impact of Intraoperative Hemodynamics Using High-Fidelity Data - Summary - MDSpire

Acute Kidney Injury After Pediatric Heart Transplant: The Impact of Intraoperative Hemodynamics Using High-Fidelity Data

  • By

  • Matthew Cummins

  • Brian Madden

  • Philip T. Thrush

  • Rajit Basu

  • Rohit S. Loomba

  • July 16, 2026

Share

Objective:

To characterize the association between intraoperative mean arterial pressure, central venous pressure, and renal near infrared spectroscopy with acute kidney injury after pediatric heart transplant.

Approach:
  • Study Design: Single-center, retrospective study at Ann & Robert H. Lurie Children’s Hospital of Chicago, focusing on pediatric patients who underwent heart transplantation.
  • Data Collection: Patient characteristics, operative data, and intraoperative physiologic data were collected from electronic health records and perfusion/anesthesia records.
  • Statistical Analyses: Continuous and categorical variables were analyzed using Mann–Whitney U test and Fisher’s exact test, respectively. Receiver operating curve analyses were performed to evaluate the discriminative ability of various intraoperative variables for postoperative ac…
Key Findings:
  • The incidence of acute kidney injury after pediatric heart transplant ranges from 49% to 66%, as reported in various studies.
  • Intraoperative mean arterial pressure, central venous pressure, and renal near infrared spectroscopy were evaluated for their association with acute kidney injury.
Interpretation:

Limitations:
  • Single-center study may limit generalizability.
  • Retrospective design may introduce bias.
Conclusion:

Original Source(s)

Related Content