To characterize the association between intraoperative mean arterial pressure, central venous pressure, and renal near infrared spectroscopy with acute kidney injury after pediatric heart transplant.
Approach:
Study Design: Single-center, retrospective study at Ann & Robert H. Lurie Children’s Hospital of Chicago, focusing on pediatric patients who underwent heart transplantation.
Data Collection: Patient characteristics, operative data, and intraoperative physiologic data were collected from electronic health records and perfusion/anesthesia records.
Statistical Analyses: Continuous and categorical variables were analyzed using Mann–Whitney U test and Fisher’s exact test, respectively. Receiver operating curve analyses were performed to evaluate the discriminative ability of various intraoperative variables for postoperative ac…
Key Findings:
The incidence of acute kidney injury after pediatric heart transplant ranges from 49% to 66%, as reported in various studies.
Intraoperative mean arterial pressure, central venous pressure, and renal near infrared spectroscopy were evaluated for their association with acute kidney injury.
Advanced heart failure does not always present as a single defining event. Referring physicians may instead notice a pattern of worsening symptoms, recurrent hospitalizations or increasing difficulty maintaining a patient’s clinical stability.
Manufacturers would be required to notify the FDA of GRAS determinations under a proposed rule, while HHS and USDA also submitted the first proposed federal definition of ultra-processed foods for final review.
