Emerging Antimicrobial Resistance and the Prevalence of Gram-Negative Bloodstream Infections in Pediatric Acute Myeloid Leukemia Patients Undergoing Induction Chemotherapy at Children’s Cancer Hospital Egypt 57357 - Summary - MDSpire
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Emerging Antimicrobial Resistance and the Prevalence of Gram-Negative Bloodstream Infections in Pediatric Acute Myeloid Leukemia Patients Undergoing Induction Chemotherapy at Children’s Cancer Hospital Egypt 57357
To determine the prevalence and antibiotic susceptibility patterns of gram-negative bloodstream infections (GNBSI) during induction chemotherapy in pediatric AML patients, highlighting the associated morbidity and mortality.
Key Findings:
27.4% of children experienced at least one GNBSI during induction chemotherapy.
80% of GNBSI cases were caused by multi-drug resistant organisms.
The most common pathogens included E. coli (54.8%), K. pneumoniae (16.9%), A. baumannii (6.5%), E. cloacae (4.8%), and P. aeruginosa (4.0%).
30-day cumulative infection-related mortality was 27.8%.
Associated morbidity included typhlitis (32.2%) and ICU admissions (42%).
Interpretation:
The high prevalence of GNBSI and antibiotic resistance in pediatric AML patients undergoing chemotherapy underscores the urgent need for improved infection control and antibiotic stewardship strategies to mitigate these risks.
Limitations:
Retrospective design may limit the comprehensiveness of data and introduce biases.
Exclusion of patients with Down syndrome and acute promyelocytic leukemia may affect generalizability.
Conclusion:
The study underscores the critical need for global surveillance of antibiotic resistance patterns and the implementation of effective antibiotic stewardship to mitigate the impact of MDR GN infections in pediatric oncology.
