Association of age at menopause with cardiovascular disease and mortality:insights from NHANES and a clinical cohort

By
Xinmiao Hong
Linxi Jin
Guoli Shang
Qiwei Chen
Zhuang Han
Shuhong Yao
Zhita Wang
Liang Li
Weidong He
Xianpei Heng
Liuqing Yang
June 23, 2026
0 min

Frontiers In Cardiovascular Medicine

Objective:

To explore the association between age at menopause and cardiovascular disease and mortality, and to identify potential mediators of this association.

Approach:

Key Findings:

Women with menopause before 40 years had higher prevalence of cardiovascular disease and increased mortality risks compared to those with menopause at 50-51 years.
Each one-year decrease in age at menopause was associated with 3% increase in cardiovascular disease prevalence, 3% increase in all-cause mortality, and 4% increase in cardiovascular mortality.
Total cholesterol, triglycerides, HDL-C, hypertension, and glycated hemoglobin partially mediated the association between age at menopause and adverse outcomes.

Interpretation:

Limitations:

The study is observational and cannot establish causation.
Potential confounding factors may not have been fully controlled.

Association of age at menopause with cardiovascular disease and mortality:insights from NHANES and a clinical cohort

Objective:

Approach:

Key Findings:

Interpretation:

Limitations:

Conclusion:

Original Source(s)

Association of age at menopause with cardiovascular disease and mortality:insights from NHANES and a clinical cohort

Related Content

How Quickly Are Patients Reaching Quadruple HFrEF Therapy?

VSMCs and the immune microenvironment: a multidimensional regulatory network driving vascular injury and repair

Molecular Interplay between hypertension and dyslipidemia in cardiovascular pathogenesis: toward precision-based therapeutic strategies