Objective:

To report a case of long-term control of systemic melanoma with pembrolizumab and successful management of breakthrough brain metastases using stereotactic radiosurgery (SRS).

Approach:

Key Findings:

• All intracranial lesions treated with SRS remained locally controlled without sustained progression.
• The patient maintained excellent functional status (Karnofsky Performance Status 90) without neurological deficits.

Interpretation:

Limitations:

• This is a single-patient observation, limiting generalizability.
• Detailed molecular and immunologic correlates were not available.

Conclusion:

Sources:

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