Efficacy and Safety of Neoadjuvant Therapies for High-Risk and Locally Advanced Prostate Cancer in Older Adults: A Systematic Review and Network Meta-Analysis - Summary - MDSpire
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Efficacy and Safety of Neoadjuvant Therapies for High-Risk and Locally Advanced Prostate Cancer in Older Adults: A Systematic Review and Network Meta-Analysis
To compare the efficacy and safety profiles of various neoadjuvant treatments in improving pathological outcomes in older adults with high-risk or locally advanced prostate cancer.
NNHT achieved the highest pathological response rates but was associated with the most frequent and severe adverse events.
Interpretation:
NNHT is the most effective neoadjuvant approach for optimizing pathological endpoints, despite a significant toxicity burden.
Limitations:
The analysis is limited to studies published until April 2025, which may not include the latest research.
Potential biases in the included studies may affect the reliability of the findings.
Conclusion:
NNHT should be prioritized in future trials aimed at evaluating long-term survival and comprehensive safety outcomes in elderly patients with high-risk prostate cancer.
