4,4′-DMAR in-vivo acute cardiotoxicity: differences between (±)cis-4,4′-DMAR and its coadministration with the (±)trans-4,4′-DMAR isomer - Summary - MDSpire

4,4′-DMAR in-vivo acute cardiotoxicity: differences between (±)cis-4,4′-DMAR and its coadministration with the (±)trans-4,4′-DMAR isomer

  • By

  • Giorgia Corli

  • Elisa Roda

  • Beatrice Marchetti

  • Micaela Tirri

  • Sabrine Bilel

  • Marta Bassi

  • Beatrice Benedetti

  • Elena Cavarretta

  • Giacomo Frati

  • Fabrizio De Luca

  • Carlo Alessandro Locatelli

  • Fabio De-Giorgio

  • Matteo Marti

  • June 16, 2026

  • 0 min

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Objective:

To investigate the cardiorespiratory effects of (±)cis-4,4′-DMAR alone and its coadministration with (±)trans-4,4′-DMAR in male mice.

Key Findings:
  • 10 mg/kg (±)cis-4,4′-DMAR and coadministration with (±)trans-4,4′-DMAR induced tachycardia and narrow-QRS arrhythmias.
  • Increased corrected QT/QT interval, tachypnea, and decreased relaxation time were observed.
  • Significant alterations in inflammation/oxidative stress markers in cardiomyocytes and blood vessel walls were noted.
Interpretation:

The study provides evidence of severe toxicity of 4,4′-DMAR to cardiac and respiratory systems, emphasizing the importance of dosage and stereoisomer coadministration.

Limitations:
  • The study was conducted only on male mice, which may limit the generalizability of the findings. Future research should explore potential sex-specific responses to the drug.
Conclusion:

The findings highlight the complex nature and potential dangers of intoxication with 4,4′-DMAR, emphasizing the need for caution in its use.

Original Source(s)

4,4′-DMAR in-vivo acute cardiotoxicity: differences between (±)cis-4,4′-DMAR and its coadministration with the (±)trans-4,4′-DMAR isomer

  • by Giorgia Corli, Elisa Roda, Beatrice Marchetti, Micaela Tirri, Sabrine Bilel, Marta Bassi, Beatrice Benedetti, Elena Cavarretta, Giacomo Frati, Fabrizio De Luca, Carlo Alessandro Locatelli, Fabio De-Giorgio, Matteo Marti

  • June 16, 2026

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