Adjuvant hyperthermic intraperitoneal chemotherapy in patients with colon cancer at high risk of peritoneal metastases: individual patient data meta-analysis - Summary - MDSpire

Adjuvant hyperthermic intraperitoneal chemotherapy in patients with colon cancer at high risk of peritoneal metastases: individual patient data meta-analysis

  • By

  • Julie J M Hamm

  • Rudolf van den Berg

  • Eleni-Rosalina Andrinopoulou

  • E Sophie Zwanenburg

  • Gijsbert D Musters

  • Pieter J Tanis

  • Alvaro Arjona-Sanchez

  • the COLOPEC and HIPECT4 Collaborator Groups

  • E S Zwanenburg

  • C E L Klaver

  • D D Wisselink

  • C J A Punt

  • P Snaebjornsson

  • J Crezee

  • A G J Aalbers

  • A R M Brandt-Kerkhof

  • A J A Bremers

  • J W A Burger

  • H F J Fabry

  • F T J Ferenschild

  • S Festen

  • W M U van Grevenstein

  • P H J Hemmer

  • I H J T de Hingh

  • N F M Kok

  • M Kusters

  • L Schoonderwoerd

  • J B Tuynman

  • A W H van de Ven

  • H L van Westreenen

  • M J Wiezer

  • D D E Zimmerman

  • A van Zweeden

  • M G W Dijkgraaf

  • G D Musters

  • M Ortega-Salas Rosa

  • A Martínez-López

  • E M Torres-Tordera

  • B Rufian-Andujar

  • F Valenzuela-Molina

  • A Gordon-Suarez

  • F J Medina-Fernandez

  • A Gomez-España

  • F Triviño-Tarradas

  • M Granados-Rodríguez

  • M C Vazquez-Borrego

  • M Garzas-Martin Almagro

  • I Inmaculada Lasa-Unzué

  • R Gómez-Sanz

  • A López-García

  • M Díez-Alonso

  • P Hernández-Juara

  • R Molina-Villaverde

  • C Castillo Torres

  • J I Busteros Moraza

  • J J Segura-Sampedro

  • R Rafael Morales-Soriano

  • C Pineño-Flores

  • A Serrano Del Moral

  • I Manzanedo

  • F Pereira

  • M E Moneva Arce

  • R Gianchandani-Moorjani

  • J M Sánchez-González

  • C Díaz-López

  • G Hernandez Hernandez

  • J G Diaz Mejias

  • M J Hernández Barroso

  • R M Abreu-Falcon

  • A Muñoz Hernández

  • V Castro López Taruella

  • C Hernandez Pérez

  • R Afonso

  • M Viña-Romero

  • R Perez-Rodriguez

  • M Heras-Garceau

  • I Ramos

  • O Crusellas Maña

  • M A Lorenzo Liñán

  • P A Parra Baños

  • M Carrasco Prats

  • M Ruiz Marín

  • E Terol Garaulet

  • F García Molina

  • I M Gallarín Salamanca

  • M González Cordero

  • A Titos García

  • S González-Moreno

  • A Mayol Oltra

  • April 29, 2025

  • 0 min

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Objective:

To evaluate the efficacy of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in reducing locoregional recurrence rates in high-risk patients with locally advanced colon cancer.

Key Findings:
  • The 36-month locoregional recurrence rate was 16.0% for HIPEC patients and 21.2% for control patients (P = 0.295).
  • Significant reduction in locoregional recurrence after HIPEC was observed in patients with right-sided tumors (HR 0.56, 95% CI 0.48 to 0.67, P < 0.001).
  • No significant differences in survival were found for the overall study population.
Interpretation:

Adjuvant HIPEC significantly reduces locoregional recurrence in right-sided locally advanced colon cancer but not in the overall population. Further research is needed to draw definitive conclusions on DFS and OS.

Limitations:
  • Low event rates in subgroups limited survival analyses.
  • Short median follow-up of 36 months may not capture long-term outcomes.
Conclusion:

HIPEC may be beneficial for reducing recurrence in right-sided colon cancer, highlighting the need for further studies to confirm these findings and explore long-term survival outcomes.

Original Source(s)

Adjuvant hyperthermic intraperitoneal chemotherapy in patients with colon cancer at high risk of peritoneal metastases: individual patient data meta-analysis

  • by Julie J M Hamm, Rudolf van den Berg, Eleni-Rosalina Andrinopoulou, E Sophie Zwanenburg, Gijsbert D Musters, Pieter J Tanis, Alvaro Arjona-Sanchez, the COLOPEC and HIPECT4 Collaborator Groups, E S Zwanenburg, C E L Klaver, D D Wisselink, C J A Punt, P Snaebjornsson, J Crezee, A G J Aalbers, A R M Brandt-Kerkhof, A J A Bremers, J W A Burger, H F J Fabry, F T J Ferenschild, S Festen, W M U van Grevenstein, P H J Hemmer, I H J T de Hingh, N F M Kok, M Kusters, L Schoonderwoerd, J B Tuynman, A W H van de Ven, H L van Westreenen, M J Wiezer, D D E Zimmerman, A van Zweeden, M G W Dijkgraaf, G D Musters, M Ortega-Salas Rosa, A Martínez-López, E M Torres-Tordera, B Rufian-Andujar, F Valenzuela-Molina, A Gordon-Suarez, F J Medina-Fernandez, A Gomez-España, F Triviño-Tarradas, M Granados-Rodríguez, M C Vazquez-Borrego, M Garzas-Martin Almagro, I Inmaculada Lasa-Unzué, R Gómez-Sanz, A López-García, M Díez-Alonso, P Hernández-Juara, R Molina-Villaverde, C Castillo Torres, J I Busteros Moraza, J J Segura-Sampedro, R Rafael Morales-Soriano, C Pineño-Flores, A Serrano Del Moral, I Manzanedo, F Pereira, M E Moneva Arce, R Gianchandani-Moorjani, J M Sánchez-González, C Díaz-López, G Hernandez Hernandez, J G Diaz Mejias, M J Hernández Barroso, R M Abreu-Falcon, A Muñoz Hernández, V Castro López Taruella, C Hernandez Pérez, R Afonso, M Viña-Romero, R Perez-Rodriguez, M Heras-Garceau, I Ramos, O Crusellas Maña, M A Lorenzo Liñán, P A Parra Baños, M Carrasco Prats, M Ruiz Marín, E Terol Garaulet, F García Molina, I M Gallarín Salamanca, M González Cordero, A Titos García, S González-Moreno, A Mayol Oltra

  • April 29, 2025

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