Reduced-Dose Radiation Shows Durable Control - Summary - MDSpire
From the Journals

Reduced-Dose Radiation Shows Durable Control

Single-arm cohort findings contrast with interim results from NRG-HN005, underscoring ongoing uncertainty around treatment deintensification.

  • By

  • Andrea Surnit

  • May 8, 2026

  • 4 min

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A cohort study published in JAMA Otolaryngology examines a 60-Gy radiotherapy regimen for p16-positive oropharyngeal carcinoma, showing low locoregional recurrence rates of 3.4% and high overall survival of 92.4% over five years. Conducted across multiple sites between 2014 and 2022, the study included 240 untreated patients with specific disease criteria and favorable smoking histories. The findings contribute to the discussion of treatment deintensification in HPV-associated conditions, though they emphasize that current standards are unchanged, and further studies are warranted.

Original Source(s)

Reduced-Dose Radiation Shows Durable Control

  • by Andrea Surnit

  • May 8, 2026

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