Transparent Fluids and Enhanced Safety in Procedures: Insights from the OCULUS Study
Objective: To examine the safety of continuing vs withholding GLP-1/GIP receptor agonists before upper endoscopy.
Approach: Study Design: The study was a randomized clinical trial assessing the effects of GLP-1/GIP RAs on procedural safety.Procedural Setting: Participants underwent procedures under moderate sedation with direct endoscopic visualization to assess gastric volume.Key Findings: No clinically significant residual gastric volume (RGV) was observed in participants on a clear liquid diet prior to the procedure. The protocol of stopping the procedure upon detecting significant RGV likely enhanced safety. Avoidance of solid food may influence gastric contents independently of medication management. Limitations: The trial was stopped early after a prespecified interim analysis, which may affect the robustness of subgroup analyses. Dietary strategies were not a primary outcome of the trial. Sources:
