Differential age-related patterns in the associations of LDL-C, TG/HDL-C ratio, and carotid plaque: a large-scale cross-sectional study in a Chinese health check-up population - Summary - MDSpire
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Age-Dependent Variations in the Relationships Between LDL-C, TG/HDL-C Ratio, and Carotid Plaque: Insights from a Large Cross-Sectional Study in a Chinese Health Screening Cohort
To characterize the age-specific heterogeneity in the associations of LDL-C and TG/HDL-C with carotid plaque.
Approach:
Participants: Retrospective analysis of 23,058 adults undergoing carotid ultrasonography, with 21,227 included after exclusions.
Methods: Multivariate logistic regression evaluated associations of LDL-C and TG/HDL-C with carotid plaque, with age-stratified analyses and interaction tests.
Key Findings:
Carotid plaque detection rate was 31.4% (6,657/21,227).
LDL-C was independently associated with plaque (OR = 1.12, 95% CI: 1.08–1.17, P < 0.001), strongest in <40 years (OR = 1.51, 95% CI: 1.30–1.76).
TG/HDL-C was also independently associated with plaque (OR = 1.11, 95% CI: 1.07–1.15, P < 0.001), stable across age groups.
LDL-C correlated with hypoechoic plaques (OR = 1.23, 95% CI: 1.16–1.30), while TyG index did not.
Interpretation:
Limitations:
Cross-sectional design limits causal inference.
Findings may not be generalizable beyond the studied cohort.
