Comparison of early clinical and optical quality-related outcomes after SMILE using VisuMax 800 versus VisuMax 500 for myopia and low-to-moderate astigmatism in a Chinese population: a single-center retrospective study - Summary - MDSpire

Comparison of early clinical and optical quality-related outcomes after SMILE using VisuMax 800 versus VisuMax 500 for myopia and low-to-moderate astigmatism in a Chinese population: a single-center retrospective study

  • By

  • Xuanyu Yang

  • Jiabin Leng

  • Yuchen Mei

  • Fei Peng

  • Yifan Xie

  • Linlin Liu

  • Linhua Wan

  • Liping Liu

  • Wentian Zhou

  • Hui Zhang

  • April 30, 2026

  • 0 min

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Objective:

To compare early clinical outcomes, centration accuracy, and optical quality-related parameters after SMILE performed using the VisuMax 800 and VisuMax 500 platforms in a Chinese population with myopia and low-to-moderate astigmatism.

Key Findings:
  • No significant differences in uncorrected or corrected distance visual acuity, safety index, or efficacy index between groups (p > 0.05).
  • SMILE Pro group had significantly shorter lenticule creation time (9.47 s vs. 27.43 s, p < 0.01).
  • Lower absolute Y-axis decentration and total optical zone decentration in the SMILE Pro group (both p < 0.01).
  • Lower postoperative vertical coma in the SMILE Pro group (p = 0.004).
  • Lower postoperative residual cylindrical error in the SMILE Pro group (p = 0.048).
Interpretation:

Both VisuMax 500 and VisuMax 800 platforms showed favorable safety and efficacy for correcting myopia and low-to-moderate astigmatism, with the SMILE Pro platform demonstrating improved centration and optical quality metrics.

Limitations:
  • Retrospective design may introduce selection bias.
  • Single-center study limits generalizability.
  • Short follow-up period of 3 months.
Conclusion:

SMILE Pro (VisuMax 800) is associated with improved outcomes compared to conventional SMILE (VisuMax 500), warranting further prospective, multicenter studies with larger sample sizes and longer follow-up.

Original Source(s)

Comparison of early clinical and optical quality-related outcomes after SMILE using VisuMax 800 versus VisuMax 500 for myopia and low-to-moderate astigmatism in a Chinese population: a single-center retrospective study

  • by Xuanyu Yang, Jiabin Leng, Yuchen Mei, Fei Peng, Yifan Xie, Linlin Liu, Linhua Wan, Liping Liu, Wentian Zhou, Hui Zhang

  • April 30, 2026

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