To report a case of cystic fibrosis (CF) in a Chinese patient presenting with nontuberculous mycobacterial infection and to review existing literature, highlighting the significance of early diagnosis and treatment.
Key Findings:
The patient had a confirmed diagnosis of cystic fibrosis with biallelic CFTR mutations.
Metagenomic sequencing identified Mycobacterium abscessus and Staphylococcus aureus in the patient's bronchoalveolar lavage fluid.
The treatment regimen included linezolid, moxifloxacin, azithromycin, and minocycline, with a focus on the patient's response to treatment.
Interpretation:
The case highlights the challenges of diagnosing CF in non-Caucasian populations and the complexities of managing coinfections with multidrug-resistant pathogens, suggesting a need for tailored clinical approaches.
Limitations:
Limited access to CFTR modulator therapy due to financial constraints.
The rarity of CF in the Chinese population may limit generalizability of findings, particularly regarding treatment responses.
Conclusion:
This case underscores the importance of early CF diagnosis and tailored treatment approaches in managing complex infections, advocating for improved access to essential medications.
