Association between the C-reactive protein-triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome - Summary - MDSpire
Advertisement
Association between the C-reactive protein-triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome
To examine the association between the C-reactive protein-triglyceride-glucose index (CTI) and the risk of coronary microvascular dysfunction (CMD) in patients with chronic coronary syndrome (CCS).
Approach:
Assessment Methods: CMD was defined by caIMR ≥ 25 U. CTI, TyG, and CRP were measured, and associations with CTI and major adverse cardiovascular events (MACE) were analyzed using Cox regression and ROC analyses.
Key Findings:
CTI was independently associated with CMD in patients with CCS (Q4 vs. Q1: OR: 2.28, 95% CI: 1.16–4.49, p = 0.017).
Higher CTI predicted increased MACE risk over a median follow-up of 35 months in CMD patients (fully adjusted HR for Q4: 2.62, 95% CI: 1.25–5.51, p = 0.011).
CTI demonstrated superior predictive accuracy for CMD-related MACE compared to TyG (DeLong test p = 0.020).
Interpretation:
CTI is a robust and independent predictor of both CMD and MACE in patients with CCS, supporting its use for early risk stratification.
Limitations:
The single-center study may limit the generalizability of the findings.
The retrospective design may introduce biases that affect the results.
Conclusion:
CTI serves as a biomarker for assessing CMD and MACE risk in CCS patients.
National survey findings suggest many US adults report making health decisions based on social media despite widespread concerns about the accuracy of health information shared to the platforms.
