Fecal Microbiota and Volatile Metabolome Pattern Alterations Precede Late-Onset Meningitis in Preterm Neonates - Summary - MDSpire

Fecal Microbiota and Volatile Metabolome Pattern Alterations Precede Late-Onset Meningitis in Preterm Neonates

  • By

  • Nina M Frerichs

  • Nancy Deianova

  • Sofia el Manouni el Hassani

  • Animesh Acharjee

  • Mohammed Nabil Quraishi

  • Willem P de Boode

  • Veerle Cossey

  • Christian V Hulzebos

  • Anton H van Kaam

  • Boris W Kramer

  • Esther d’Haens

  • Wouter J de Jonge

  • Daniel C Vijlbrief

  • Mirjam M van Weissenbruch

  • Emma Daulton

  • Alfian N Wicaksono

  • James A Covington

  • Marc A Benninga

  • Nanne K H de Boer

  • Johannes B van Goudoever

  • Hendrik J Niemarkt

  • Tim G J de Meij

  • May 23, 2024

  • 0 min

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Objective:

To identify changes in fecal microbiota composition and volatile metabolomics preceding late-onset neonatal meningitis (LOM) in preterm infants, highlighting the importance of early detection.

Key Findings:
  • 21 out of 1397 infants were diagnosed with LOM (1.5%), with 90% also having concomitant late-onset sepsis (LOS), indicating a significant overlap that may complicate diagnosis.
  • A random forest model based on 6 microbiota features predicted LOM with an AUC of 0.88, suggesting a strong potential for clinical application.
  • Volatile metabolome analysis showed moderate predictive ability with an AUC of 0.70–0.76 in the 3 days pre-LOM, indicating a need for further refinement.
Interpretation:

Fecal microbiota composition changes can serve as a potential early indicator for LOM in preterm infants, while volatile metabolome alterations show moderate association, warranting further exploration of their clinical utility.

Limitations:
  • The study's sample size for LOM cases was small (21 infants), which may limit the generalizability of the findings.
  • No single discriminative metabolites were identified by GC-TOF-MS, suggesting the need for more sensitive detection methods.
Conclusion:

Preclinical changes in fecal microbiota may provide a noninvasive diagnostic biomarker for LOM in preterm infants, warranting further investigation into specific microbiota profiles and their clinical implications.

Original Source(s)

Fecal Microbiota and Volatile Metabolome Pattern Alterations Precede Late-Onset Meningitis in Preterm Neonates

  • by Nina M Frerichs, Nancy Deianova, Sofia el Manouni el Hassani, Animesh Acharjee, Mohammed Nabil Quraishi, Willem P de Boode, Veerle Cossey, Christian V Hulzebos, Anton H van Kaam, Boris W Kramer, Esther d’Haens, Wouter J de Jonge, Daniel C Vijlbrief, Mirjam M van Weissenbruch, Emma Daulton, Alfian N Wicaksono, James A Covington, Marc A Benninga, Nanne K H de Boer, Johannes B van Goudoever, Hendrik J Niemarkt, Tim G J de Meij

  • May 23, 2024

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