Framingham risk score associates with incident cancer and heart failure - Summary - MDSpire

Framingham risk score associates with incident cancer and heart failure

  • By

  • Pieter F van den Berg

  • Laura I Yousif

  • Yvonne Koop

  • Ezgi Hatip Ünlü

  • Melis Asik

  • Bart J van Essen

  • Kevin Damman

  • Adriaan A Voors

  • Nabil V Sayour

  • Thomas F Kok

  • Yiqian Yang

  • Isabella Kardys

  • Stephan J L Bakker

  • Bert van der Vegt

  • Navin Suthahar

  • Rudolf A de Boer

  • Wouter C Meijers

  • September 27, 2025

  • 0 min

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Objective:

To examine the association between Framingham risk score (FRS) tertiles and the incidence of cancer and heart failure (HF), highlighting its clinical significance.

Key Findings:
  • Participants in the highest FRS tertile had a higher hazard for new-onset cancer (sHR 2.32, P < 0.001) and HF (sHR 10.08, P < 0.001) compared to the lowest tertile in PREVEND.
  • In the UK Biobank, the highest FRS tertile also showed increased hazards for cancer (sHR 2.05, P < 0.001) and HF (sHR 5.99, P < 0.001).
  • Higher FRS tertile was associated with worse survival outcomes (log-rank P < 0.001).
Interpretation:

The FRS may serve as a useful tool for predicting not only cardiovascular disease but also the risk of cancer and heart failure, suggesting a need for integrated risk assessment in clinical practice to improve patient outcomes.

Limitations:
  • The study is observational and cannot establish causation.
  • Potential confounding factors, such as specific lifestyle or genetic factors, may not have been fully accounted for.
Conclusion:

The findings indicate that the FRS could be beneficial for identifying individuals at risk for both cancer and heart failure, potentially leading to improved preventive strategies and influencing clinical guidelines.

Original Source(s)

Framingham risk score associates with incident cancer and heart failure

  • by Pieter F van den Berg, Laura I Yousif, Yvonne Koop, Ezgi Hatip Ünlü, Melis Asik, Bart J van Essen, Kevin Damman, Adriaan A Voors, Nabil V Sayour, Thomas F Kok, Yiqian Yang, Isabella Kardys, Stephan J L Bakker, Bert van der Vegt, Navin Suthahar, Rudolf A de Boer, Wouter C Meijers

  • September 27, 2025

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