Longitudinal Analysis of Plasma Proteomic Alterations After BNT162b2 COVID-19 Booster Vaccination in Qatar - Summary - MDSpire

Longitudinal Analysis of Plasma Proteomic Alterations After BNT162b2 COVID-19 Booster Vaccination in Qatar

  • By

  • Sana Bentebbal

  • Ahmed Zaqout

  • Bakhita Meqbel

  • Ilham Bensmail

  • Abdullah Aldushain

  • Alberto de la Fuente

  • Remy Thomas

  • Adviti Naik

  • Hibah Shaath

  • Neyla S. Al-Akl

  • Abdi Adam

  • Houda Y. A. Moussa

  • Kyung C. Shin

  • Rowaida Z. Taha

  • Mohammed Abukhattab

  • Muna A. Al-Maslamani

  • Nehad M. Alajez

  • Abdelilah Arredouani

  • Yongsoo Park

  • Sara A. Abdulla

  • Omar M. A. El-Agnaf

  • Houari B. Abdesselem

  • Ali S. Omrani

  • Julie Decock

  • April 24, 2026

  • 0 min

Share

Objective:

To assess the effects of the third BNT162b2 mRNA vaccine dose on the circulating proteome over a period of 6 months, highlighting its significance in ongoing vaccination efforts.

Key Findings:
  • Infection-naïve individuals showed alterations in 11 proteins at 3 months and 8 proteins at 6 months post-booster, including significant statistical values.
  • Significant sustained increase in PARP-1 and decrease in MMP-7 were observed in both infection-naïve and previously infected individuals, with specific fold changes and p-values.
  • Dysregulation of key inflammatory proteins was noted for up to 6 months post-booster, with detailed statistical significance.
Interpretation:

The findings highlight the temporal dynamics of circulating proteomic responses post-booster vaccination, indicating potential implications for immune readiness and inflammatory processes, which could inform future vaccination strategies.

Limitations:
  • The study involved a limited sample size of 70 individuals, which may affect the generalizability of the findings.
  • The focus was solely on plasma proteomics without assessing other immune responses, which could provide a more comprehensive understanding.
Conclusion:

The study provides insights into the molecular features of immune responses following booster vaccination, which may inform future vaccination strategies and public health policies.

Original Source(s)

Longitudinal Analysis of Plasma Proteomic Alterations After BNT162b2 COVID-19 Booster Vaccination in Qatar

  • by Sana Bentebbal, Ahmed Zaqout, Bakhita Meqbel, Ilham Bensmail, Abdullah Aldushain, Alberto de la Fuente, Remy Thomas, Adviti Naik, Hibah Shaath, Neyla S. Al-Akl, Abdi Adam, Houda Y. A. Moussa, Kyung C. Shin, Rowaida Z. Taha, Mohammed Abukhattab, Muna A. Al-Maslamani, Nehad M. Alajez, Abdelilah Arredouani, Yongsoo Park, Sara A. Abdulla, Omar M. A. El-Agnaf, Houari B. Abdesselem, Ali S. Omrani, Julie Decock

  • April 24, 2026

Related Content

Long COVID as a network disorder: a mechanism-anchored framework for biological stratification and therapeutic targeting

Hantavirus Outbreak Revives COVID-Era False Health Claims — The Monitor

Serum cytokine profiling reveals CXCL10 (IP-10) as a major predictor of severe COVID-19 outcomes in hospitalized patients during the first pandemic wave in Italy