Discrepancies in Cardiac Output Measurements: A Comparison of Pressure Recording Analytical Method and Pulmonary Artery Thermodilution in Low Cardiac Output Patients - Initial Findings from a Prospective Observational Pilot Study - Summary - MDSpire
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Discrepancies in Cardiac Output Measurements: A Comparison of Pressure Recording Analytical Method and Pulmonary Artery Thermodilution in Low Cardiac Output Patients - Initial Findings from a Prospective Observational Pilot Study
To investigate the feasibility of the PRAM method in high-risk cardiac surgery patients with severely impaired left ventricular ejection fraction (LVEF < 35%) and to analyze the agreement between PRAM-derived and PAC-derived continuous cardiac output measurements.
Approach:
Key Findings:
High feasibility of data acquisition (98.8%).
PRAM showed significant underestimation of cardiac output by -2.02 L/min compared to PAC (limits of agreement: -5.69 to 1.64 L/min).
Poor trending ability with a four-quadrant concordance rate of 36.6% and polar concordance rate of 10.1%.
Interpretation:
The PRAM method demonstrated poor agreement and unreliable trending ability in patients with severely reduced left ventricular function, suggesting significant limitations in its accuracy under these conditions and potential implications for clinical decision-making.
Limitations:
Small sample size (n = 7) limits generalizability and may affect the reliability of findings.
Study conducted in a specific high-risk population may not reflect broader patient demographics.
Conclusion:
While feasible for data acquisition, PRAM's accuracy and reliability in low-output cardiac surgery patients require further investigation to understand its limitations in this context.
