To characterize the relationship between iris color and accommodative amplitude, pupil diameter, and myopia progression in response to low-concentration atropine eye drops in children and adolescents.
Approach:
Key Findings:
Atropine 0.01% and 0.05% eye drops showed varying efficacy in controlling myopia progression, with specific p-values indicating statistical significance.
Statistically significant differences in axial length change were observed between White and non-White ethnicities in the MOSAIC study, with p = 0.002.
Iris color may influence the response to atropine treatment, with lighter iris colors potentially experiencing greater effects, warranting further investigation.
Interpretation:
The findings suggest that iris color could be a factor in the efficacy of low-concentration atropine for myopia control, highlighting the need for personalized treatment approaches.
Limitations:
Subgroup analyses were not adequately powered to detect significant differences, which may limit the reliability of findings.
Variability in iris color classification and measurement methods across studies may affect comparability and interpretation of results.
Conclusion:
Further research is needed to explore the implications of iris color on atropine treatment efficacy, particularly in diverse populations, and to optimize myopia management strategies.
by Gareth Lingham, James Loughman, Samantha SY Lee, Michael X. Repka, Eoin Kerin, Alicia Gómez Sánchez, Emmanuel Kobia-Acquah, Ernest Kyei Nkansah, Ian Flitcroft, David A. Mackey
Aqueous humor sampling confirmed iris metastasis in a patient with refractory secondary glaucoma and lung adenocarcinoma, avoiding iris tissue sampling.
