Objective:

To assess BPV from ABPM for subclinical target organ damage (TOD) prediction in hypertension.

Approach:

• Study Design: Retrospective study screening 180 essential hypertension patients, with 176 enrolled after exclusions.
• ABPM Examination: Participants underwent standardized 24-h ABPM examination to calculate BPV parameters.
• Statistical Analysis: Multivariate logistic regression and ROC curve analysis were used to evaluate BPV indices as predictors of subclinical TOD.

Key Findings:

• 94 patients were assigned to the TOD group and 82 to the non-TOD group.
• The TOD group had significantly higher 24-h, daytime, and nighttime BP SD, CV, and ARV (all P < 0.001).
• Nighttime SBP SD, 24-h SBP ARV, and nighttime SBP ARV were identified as independent predictors of subclinical TOD (all P < 0.05).
• Nighttime SBP SD had an AUC of 0.837 (95% CI: 0.773–0.901), with a cutoff of 12.25 mmHg, sensitivity of 89.4%, and specificity of 78.0%.

Interpretation:

Nighttime SBP variability (SD) from ABPM predicts subclinical TOD.

Limitations:

• The study is retrospective and may have inherent biases.
• The sample size, while adequate, may limit the generalizability of findings.

Conclusion:

Nighttime SBP variability (SD) from ABPM is a predictor of subclinical TOD in hypertension.