To report a rare case of fibrin-associated large B-cell lymphoma (FA-LBCL) originating from cystic lymphangiomatous lesions of the adrenal gland, emphasizing its rarity and to describe its cytomorphological, immunohistochemical, and molecular features.
Key Findings:
FA-LBCL is an uncommon EBV-positive B-cell malignancy associated with chronic fibrin accumulation, which complicates diagnosis.
The patient was diagnosed incidentally during surgical resection for non-neoplastic reasons, underscoring the need for vigilance.
Histological examination revealed neoplastic cells with a high proliferative index, suggesting aggressive behavior, and characteristic immunophenotype.
Interpretation:
FA-LBCL can present as a cystic lesion in the adrenal gland, complicating diagnosis due to its rarity and non-invasive nature, necessitating increased awareness among clinicians.
Limitations:
Limited literature on FA-LBCL, primarily consisting of case reports, which may hinder understanding and recognition.
Molecular testing for B-cell monoclonality was not performed due to inadequate DNA, potentially affecting diagnostic accuracy.
Conclusion:
This case highlights the importance of considering FA-LBCL in differential diagnoses of cystic adrenal lesions, emphasizing the need for awareness of this rare lymphoma subtype among healthcare professionals.
