Transcranial magnetic stimulation combined with virtual reality improves quality of life in patients with Parkinson’s disease with depression - Summary - MDSpire

Transcranial magnetic stimulation combined with virtual reality improves quality of life in patients with Parkinson’s disease with depression

  • By

  • Ruiping Gu

  • Guizhen Zeng

  • June 11, 2026

  • 0 min

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Objective:

To determine whether combining transcranial magnetic stimulation (TMS) with virtual reality (VR) provides superior improvement in quality of life, depression and anxiety symptoms, cognitive function, and motor performance in patients with Parkinson’s disease with depression (PD-D), compared with TMS alone.

Key Findings:
  • Both treatment groups showed significant improvement in HAMA-14, HAMD-17, UPDRS-III scores, and PDQ-39 total scores post-treatment, with the TMS + VR group showing more pronounced improvements (all p < 0.001).
  • No statistically significant difference in adverse effects between the two groups (p > 0.05).
Interpretation:

Limitations:
  • Study limited to a specific hospital setting and time frame.
  • Potential biases in patient selection based on treatment willingness.
Conclusion:

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