Afferent loop syndrome secondary to recurrent pancreatic adenocarcinoma post-Whipple procedure: case report - Summary - MDSpire

Afferent loop syndrome secondary to recurrent pancreatic adenocarcinoma post-Whipple procedure: case report

  • By

  • Justin Baik

  • Neil Hughes

  • Vladimir Ferrer

  • June 15, 2026

  • 0 min

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Objective:

To present a case of afferent loop syndrome (ALS) following pancreaticoduodenectomy due to recurrent pancreatic adenocarcinoma.

Approach:
    Key Findings:
    • ALS is a rare but serious complication post-Whipple surgery, often due to recurrent malignancy.
    • Persistent watery diarrhea can precede acute obstruction, complicating diagnosis.
    • Endoscopic decompression with self-expanding metal stents is an effective palliative strategy.
    Interpretation:

    Limitations:
    • The case highlights a single patient experience, limiting generalizability.
    • Only a few confirmed ALS cases from pancreatic cancer recurrence have been reported.
    Conclusion:

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