Prognostic Indicators and Clinical Characteristics of Brain Metastases in Ovarian Cancer: A Retrospective Analysis of 129 Cases Across Multiple Centers - Summary - MDSpire

Prognostic Indicators and Clinical Characteristics of Brain Metastases in Ovarian Cancer: A Retrospective Analysis of 129 Cases Across Multiple Centers

  • By

  • Yingying Wang

  • Qiyue Chao

  • Xiaoyan Lu

  • Yichi Zhou

  • Zhiwen Xie

  • Shiyun Zhang

  • Fei Xu

  • Sikao Wu

  • Lvzhong Hu

  • Bo Ding

  • Xinyi Zhang

  • Tianmin Xu

  • Guantai Ni

  • Jing Liang

  • Jinhua Zhou

  • Yang Shen

  • Bo Yang

  • Shengtao Zhou

  • Xiaojun Chen

  • Tingyan Shi

  • Chunyan Lan

  • Tao Zhu

  • Ying Zhou

  • November 7, 2025

  • 0 min

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Objective:

To evaluate current management practices and examine the distinctive clinical features of brain metastases in ovarian cancer, aiming to enhance care quality through improved understanding.

Key Findings:
  • 62.8% of patients died by the end of the study, indicating a high mortality rate.
  • Median interval from primary ovarian cancer diagnosis to brain metastasis development was 25.74 months, suggesting a delayed onset.
  • Median survival time from brain metastasis diagnosis to death was 19.53 months, highlighting the need for timely intervention.
  • Independent predictors of poor prognosis included serum CA125 levels >100 U/mL, multiple brain metastases, and headache attributed to brain metastases.
Interpretation:

The findings suggest that specific clinical features and biomarkers can guide prognosis in patients with brain metastases from ovarian cancer, emphasizing the need for tailored treatment strategies to improve outcomes.

Limitations:
  • Retrospective design may introduce bias, potentially affecting the reliability of the findings.
  • Limited generalizability due to single-country study, which may not reflect global practices.
  • Exclusion of patients with incomplete information may affect results, leading to potential underrepresentation of certain patient characteristics.
Conclusion:

A comprehensive understanding of clinical characteristics and prognostic indicators is essential for improving management strategies for brain metastases in ovarian cancer, addressing existing treatment gaps.

Original Source(s)

Prognostic Indicators and Clinical Characteristics of Brain Metastases in Ovarian Cancer: A Retrospective Analysis of 129 Cases Across Multiple Centers

  • by Yingying Wang, Qiyue Chao, Xiaoyan Lu, Yichi Zhou, Zhiwen Xie, Shiyun Zhang, Fei Xu, Sikao Wu, Lvzhong Hu, Bo Ding, Xinyi Zhang, Tianmin Xu, Guantai Ni, Jing Liang, Jinhua Zhou, Yang Shen, Bo Yang, Shengtao Zhou, Xiaojun Chen, Tingyan Shi, Chunyan Lan, Tao Zhu, Ying Zhou

  • November 7, 2025

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