To assess relationships among epigenetic aging, brain injury, socioeconomic status, and neurodevelopment in children born preterm, including whether associations between epigenetic aging and outcomes vary by brain injury severity and maternal education.
Approach:
Study design and participants: Prospective cohort of 195 infants born at 24 to 32 weeks’ gestation, recruited from two Canadian hospitals between 2015 and 2019. The present analysis included 102 participants with epigenetic data; none were lost to follow-up. Infants with congenital brain malformations or congenital infections were excluded.
Measures: Investigators recorded clinical and demographic characteristics from medical records at neonatal intensive care unit admission and updated them at study visits. The study assessed relationships among epigenetic aging, brain injury, maternal education, and neurodevelopmental outcomes; the supplied context does not specify the assessment instruments or full measurement procedures.
Interpretation:
The supplied context describes the study rationale, hypothesis, and methods but does not provide results for the current analysis.
Limitations:
Epigenetic data were available for 102 of the 195 recruited infants.
by Rhandi Christensen, Chaini Konwar, Beryl C. Zhuang, Julia MacIsaac, Vann Chau, Mehmet N. Cizmeci, Linh G. Ly, Ting Guo, Helen Branson, Michael S. Kobor, Ruth E. Grunau, Steven P. Miller
Phoenix Children’s has promoted four division chiefs from within the health system to lead vital areas including pediatric intensive care, cardiovascular intensive care, nephrology and physical medicine and rehabilitation.
