Rare Skin Reaction Reported With Tirzepatide - Summary - MDSpire
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Rare Skin Reaction Reported With Tirzepatide

A single case report described possible lichen planus pigmentosus inversus following tirzepatide initiation.

  • By

  • Andrea Surnit

  • May 7, 2026

  • 3 min

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Objective:

To report a case of lichen planus pigmentosus inversus associated with tirzepatide use, highlighting its rarity in patients with Fitzpatrick skin type II.

Key Findings:
  • Lichen planus pigmentosus inversus developed 6 to 7 months after tirzepatide initiation, a rare occurrence in Fitzpatrick skin type II.
  • The condition is typically reported in patients with Fitzpatrick skin types III-IV.
  • No new medications were reported by the patient in the preceding 2 years.
Interpretation:

The timing of the skin reaction supports a potential drug-induced lichenoid eruption, suggesting a need for further investigation into the mechanism.

Limitations:
  • Causal interpretation is limited due to lack of drug discontinuation or rechallenge.
  • The report cannot establish incidence or recurrence risk.
  • No follow-up data on the patient's condition post-treatment.
Conclusion:

This case adds to the limited reports of skin reactions associated with GLP-1 receptor agonists, suggesting a need for further investigation into the mechanisms and broader implications.

Original Source(s)

Rare Skin Reaction Reported With Tirzepatide

  • by Andrea Surnit

  • May 7, 2026

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