Acute injury characteristics predict chronic neuropathic pain development after spinal cord injury - Summary - MDSpire

Acute injury characteristics predict chronic neuropathic pain development after spinal cord injury

  • By

  • Kenneth A. Fond

  • Mayra Arellano

  • Abel Torres-Espin

  • Austin Chou

  • Xuan Bradfield

  • Sara L. Moncivais

  • J. Russell Huie

  • Debra D. Hemmerle

  • Anastasia V. Keller

  • Vineeta Singh

  • Lisa U. Pascual

  • Anthony M. DiGiorgio

  • Jason F. Talbott

  • William D. Whetstone

  • Jonathan Z. Pan

  • Philip R. Weinstein

  • Sanjay S. Dhall

  • Rajiv Saigal

  • Adam R. Ferguson

  • Jacqueline C. Bresnahan

  • Michael S. Beattie

  • Nikos Kyritsis

  • June 16, 2026

  • 0 min

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Objective:

To assess neuropathic pain outcomes in spinal cord injury (SCI) patients and identify acute care variables predictive of chronic neuropathic pain development.

Approach:
    Key Findings:
    • 36 out of 61 patients (59%) reported chronic neuropathic pain after SCI.
    • Four significant predictors of chronic neuropathic pain were identified: total number of systemic injuries, injury severity score (ISS), lower limb total motor score, and sensory pinprick total score.
    • The logistic regression model achieved a balanced accuracy of 74.3% and an AUC of 0.708, with further context on clinical relevance to be added.
    Interpretation:

    Limitations:
    • The study's sample size was limited to 61 patients, which may affect the generalizability of the findings.
    • Further validation in larger, independent cohorts is needed.
    Conclusion:

Original Source(s)

Acute injury characteristics predict chronic neuropathic pain development after spinal cord injury

  • by Kenneth A. Fond, Mayra Arellano, Abel Torres-Espin, Austin Chou, Xuan Bradfield, Sara L. Moncivais, J. Russell Huie, Debra D. Hemmerle, Anastasia V. Keller, Vineeta Singh, Lisa U. Pascual, Anthony M. DiGiorgio, Jason F. Talbott, William D. Whetstone, Jonathan Z. Pan, Philip R. Weinstein, Sanjay S. Dhall, Rajiv Saigal, Adam R. Ferguson, Jacqueline C. Bresnahan, Michael S. Beattie, Nikos Kyritsis

  • June 16, 2026

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