The diagnostic yield of an elaborate workup for comorbidities in a real-life heart failure with preserved ejection fraction outpatient population - Summary - MDSpire
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The diagnostic yield of an elaborate workup for comorbidities in a real-life heart failure with preserved ejection fraction outpatient population
To evaluate the diagnostic yield (the effectiveness of identifying new comorbidities) of standardized routine workup for comorbidities in patients with heart failure with preserved ejection fraction (HFpEF) and provide actionable insights for clinicians.
Key Findings:
A median of three pre-existing comorbidities was known per patient, with one additional comorbidity diagnosed during the workup. Pre-existing comorbidities included hypertension (74%), diabetes (23%), hypercholesterolaemia (36%), and obesity (45%).
Commonly diagnosed new comorbidities included sleep apnoea (33%) and iron deficiency (35%).
Pre-existing comorbidities often received suboptimal guideline-directed therapy, particularly diabetes (23%), hypercholesterolaemia (36%), and obesity (45%).
Interpretation:
Routine comorbidity screening in HFpEF patients significantly improves the detection of undiagnosed conditions, enhances management strategies, and is crucial for optimizing patient care.
Limitations:
Single-centre study may limit generalizability of findings, particularly in diverse populations.
Potential selection bias due to referral patterns may affect the representativeness of the patient population.
Conclusion:
Systematic screening for comorbidities in HFpEF patients is essential for identifying hidden conditions and optimizing treatment, ultimately improving patient outcomes.
by Sanne G J Mourmans, Anouk Achten, Jerremy Weerts, Marijne Scheepers, Arantxa Barandiarán Aizpurua, Michiel Henkens, Nicole Uszko-Lencer, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Vanessa P M van Empel
