Ethnic Disparities in Extrahepatic Manifestations Among People With HCV Infection: A Population-Based Study in British Columbia - Summary - MDSpire

Ethnic Disparities in Extrahepatic Manifestations Among People With HCV Infection: A Population-Based Study in British Columbia

  • By

  • Dahn Jeong

  • Stanley Wong

  • Héctor A Velásquez García

  • Prince A Adu

  • Jean D Makuza

  • Sofia R Bartlett

  • Alnoor Ramji

  • Eric M Yoshida

  • Richard L Morrow

  • Amee R Manges

  • Mohammad E Karim

  • Amanda Yu

  • Georgine Cua

  • Mel Krajden

  • Naveed Z Janjua

  • September 1, 2025

  • 0 min

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Objective:

To examine ethnic disparities in extrahepatic manifestations (EHMs) among individuals diagnosed with chronic hepatitis C virus (HCV) in British Columbia (BC), Canada, highlighting the significance of these disparities for public health.

Key Findings:
  • South and East Asians had higher incidence rates of CKD, ESRD, T2DM, stroke, and MACE compared to other ethnicities, particularly among untreated individuals, with a total sample size of 41,874.
  • Untreated South Asians had a significantly higher risk of CKD and ESRD (aHR 1.27) and T2DM (aHR 2.12).
  • Disparities largely disappeared post-HCV treatment, except for diabetes, indicating the need for targeted interventions.
Interpretation:

The study highlights a disproportionate burden of EHMs among Asian populations in BC, indicating the importance of HCV treatment in reducing ethnic disparities and informing public health policy.

Limitations:
  • Limited understanding of intra-ethnic differences and mechanisms underlying disparities, including potential confounding factors.
  • Potential biases in healthcare access patterns across ethnic groups that may affect the results.
Conclusion:

Public health programming is needed to increase linkage to HCV treatment among untreated individuals, and further research should explore the mechanisms behind these disparities, particularly intra-ethnic differences.

Original Source(s)

Ethnic Disparities in Extrahepatic Manifestations Among People With HCV Infection: A Population-Based Study in British Columbia

  • by Dahn Jeong, Stanley Wong, Héctor A Velásquez García, Prince A Adu, Jean D Makuza, Sofia R Bartlett, Alnoor Ramji, Eric M Yoshida, Richard L Morrow, Amee R Manges, Mohammad E Karim, Amanda Yu, Georgine Cua, Mel Krajden, Naveed Z Janjua

  • September 1, 2025

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