Combination of Yaobitong capsules and lumbar oblique pull manipulation for moderate pain in lumbar disc herniation with radiculopathy: a multicenter, randomized, three-arm, parallel-group controlled trial - Summary - MDSpire

Combination of Yaobitong capsules and lumbar oblique pull manipulation for moderate pain in lumbar disc herniation with radiculopathy: a multicenter, randomized, three-arm, parallel-group controlled trial

  • By

  • Guangqi Lu

  • Minghui Zhuang

  • Bin Tang

  • Jirong Zhao

  • Shaofeng Yang

  • Jiayi Guo

  • Ping Wang

  • Yikai Li

  • Shaojun Li

  • Bolai Chen

  • Puwei Yuan

  • Hong Jiang

  • Yusong Jia

  • Bin Shi

  • Xuefeng Guan

  • Yanming Xie

  • Minshan Feng

  • Zhefeng Jin

  • Jinjing Wang

  • Zelong Zhao

  • Jiawen Zhan

  • Xunlu Yin

  • He Yin

  • Ming Chen

  • Kai Sun

  • Xin Chen

  • Jie Yu

  • Liguo Zhu

  • June 26, 2026

  • 0 min

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Objective:

To evaluate the efficacy and safety of combining Yaobitong (YBT) capsules with lumbar oblique pull manipulation (LOPM) in patients with lumbar disc herniation with radiculopathy (LDHR) experiencing moderate pain.

Approach:
  • Study Design: A multicenter, randomized, three-arm, parallel-group controlled trial conducted at 13 tertiary hospitals in China.
  • Participants: 426 LDHR patients aged 18 to 65 with moderate pain (VAS score ≥ 4 to < 7) were randomly assigned to YBT alone, LOPM alone, or a combination of both.
  • Outcome Measures: Primary outcome was change in the Oswestry Disability Index (ODI) from baseline to week 2; secondary outcomes included leg pain VAS scores, low back pain VAS scores, SF-12, adverse events, and disc resorption rates.
Key Findings:
  • At 2 weeks, mean reduction in ODI was −19.4 for YBT, −19.4 for LOPM, and −21.1 for the combination group.
  • No statistically significant differences in ODI reduction or secondary outcomes between groups at any follow-up time point (all p > 0.05).
  • No safety concerns were observed in any of the groups during the 2-week intervention.
Interpretation:

The combination therapy with YBT and LOPM was not superior to either monotherapy in improving functional disability, pain, or quality of life among LDHR patients with moderate pain.

Limitations:
  • The study only assessed outcomes up to 26 weeks, limiting long-term efficacy evaluation.
  • Participants were restricted to those with moderate pain, which may not generalize to all LDHR patients.
Conclusion:

The combination of YBT and LOPM does not provide additional benefits over monotherapy for LDHR patients with moderate pain.

Sources:

Original Source(s)

Combination of Yaobitong capsules and lumbar oblique pull manipulation for moderate pain in lumbar disc herniation with radiculopathy: a multicenter, randomized, three-arm, parallel-group controlled trial

  • by Guangqi Lu, Minghui Zhuang, Bin Tang, Jirong Zhao, Shaofeng Yang, Jiayi Guo, Ping Wang, Yikai Li, Shaojun Li, Bolai Chen, Puwei Yuan, Hong Jiang, Yusong Jia, Bin Shi, Xuefeng Guan, Yanming Xie, Minshan Feng, Zhefeng Jin, Jinjing Wang, Zelong Zhao, Jiawen Zhan, Xunlu Yin, He Yin, Ming Chen, Kai Sun, Xin Chen, Jie Yu, Liguo Zhu

  • June 26, 2026

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