Hodgkin lymphoma with hypereosinophilia in a pediatric patient: case report and review of the literature - Summary - MDSpire

Hodgkin lymphoma with hypereosinophilia in a pediatric patient: case report and review of the literature

  • By

  • Rosa Margarita Cruz Osorio

  • Regina M. Navarro-Martin del Campo

  • Wangky Carolina Carrasco-Rivera

  • Lisette Paola Bruijnzeels-Ponce

  • Jesús Alejandro Gutiérrez-Ortiz

  • Hannali Quintero-Buenrostro

  • Violeta Salceda-Rivera

  • Manuel Donovan Martinez-Albarran

  • Diego Ugalde-Aviña

  • Veronica Soto Chavez

  • Fernando Sánchez-Zubieta

  • Oscar Gonzalez-Ramella

  • May 20, 2026

  • 0 min

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Objective:

To report a rare case of profound hypereosinophilia in a pediatric patient with classical Hodgkin lymphoma and review related literature, emphasizing its clinical significance.

Key Findings:
  • The patient exhibited extreme hypereosinophilia (>97,000/µL) alongside classical Hodgkin lymphoma.
  • Bone marrow analysis showed eosinophilic predominance without evidence of other malignancies.
  • Treatment with OEPA/COPDAC followed by radiotherapy led to a complete metabolic response.
Interpretation:

This case highlights the unusual association of extreme hypereosinophilia with classical Hodgkin lymphoma, suggesting a need for awareness of oncologic causes in patients with unexplained eosinophilia, particularly in pediatric populations.

Limitations:
  • The rarity of similar cases in literature limits broader conclusions, necessitating more comprehensive studies.
  • Further studies are needed to understand the mechanisms linking hypereosinophilia and Hodgkin lymphoma.
Conclusion:

The case underscores the importance of considering Hodgkin lymphoma in differential diagnoses for patients presenting with unexplained hypereosinophilia, particularly in pediatric populations, to improve early diagnosis and treatment.

Original Source(s)

Hodgkin lymphoma with hypereosinophilia in a pediatric patient: case report and review of the literature

  • by Rosa Margarita Cruz Osorio, Regina M. Navarro-Martin del Campo, Wangky Carolina Carrasco-Rivera, Lisette Paola Bruijnzeels-Ponce, Jesús Alejandro Gutiérrez-Ortiz, Hannali Quintero-Buenrostro, Violeta Salceda-Rivera, Manuel Donovan Martinez-Albarran, Diego Ugalde-Aviña, Veronica Soto Chavez, Fernando Sánchez-Zubieta, Oscar Gonzalez-Ramella

  • May 20, 2026

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