To evaluate the analgesic effect of intravenous lidocaine in patients undergoing modified radical mastectomy (MRM) with either sevoflurane or propofol maintenance anesthesia.
Key Findings:
Lidocaine infusion significantly reduced resting and active AUC for NRS score at 24 hours postoperatively compared to control groups (P < 0.001).
Lower resting and active NRS scores were observed at 3, 6, and 12 hours post-surgery in lidocaine groups (all P < 0.001).
Postoperative serum levels of inflammatory markers (IL-6, IL-1β, TNF-α, NF-κB) were significantly lower in lidocaine groups compared to controls (P < 0.001).
No significant differences in anesthetic and analgesic consumption, adverse events, or patient satisfaction among the four groups.
Interpretation:
Intravenous lidocaine infusion reduced acute postoperative pain and attenuated early systemic inflammatory response in MRM patients, independent of the maintenance anesthetic used (sevoflurane or propofol).
Limitations:
Multiple confounding factors, such as patient demographics and comorbidities, may affect the results due to the study design.
Further randomized controlled trials are required to confirm causality and assess long-term outcomes.
Conclusion:
Intravenous lidocaine may be an effective adjunct for managing postoperative pain in MRM patients, potentially improving recovery outcomes.
