Objective:

To analyze research trends of colorectal cancer organoids and identify global research hotspots and prospective directions.

Key Findings:

• A total of 2239 relevant publications were included.
• There has been explosive growth in publications over the past 16 years.
• China and the United States are the main contributors to this research area.
• Utrecht University is the most productive institution.
• Hans Clevers is the leading author with the highest total citations and publications.
• Cancers is the most productive journal, while Nature is the most frequently cited.
• Current research hotspots include drug screening, tumor microenvironment, tumor immunity, and precision oncology.

Interpretation:

Research on colorectal cancer organoids is evolving from basic model construction to high-fidelity disease models, focusing on tumor microenvironment simulation and personalized therapy.

Limitations:

• The study is limited to publications indexed in specific databases (WOSCC and Scopus).
• Future projections extend only to 2025, which may not capture long-term trends.

Conclusion:

Colorectal cancer organoids are expected to have broader clinical applications in precision oncology, with a shift towards personalized cancer therapy.