Incidence of Recurrent Invasive Pneumococcal Disease in Canada - Summary - MDSpire

Incidence of Recurrent Invasive Pneumococcal Disease in Canada

  • By

  • Leah J. Ricketson

  • Altynay Shigayeva

  • Irina Rajakumar

  • Zoe Zhong

  • Kazi Hassan

  • Irene Martin

  • Alyssa Golden

  • Allison J. McGeer

  • James D. Kellner

  • Calgary Area Epidemiology Research Group and the Toronto Invasive Bacterial Diseases Network

  • Chingiz Amirov

  • Neil Rau

  • Danny Chen

  • Jeff Powis

  • Amna Faheem

  • Kevin Katz

  • Valerie Sales

  • Samir Patel

  • Abdelbaset Belhaj

  • Reena Lovinsky

  • David Rose

  • Christie Vermeiren

  • Tony Mazzulli

  • Jennie Johnstone

  • Karen Green

  • Michael Lingley

  • Andrew Simor

  • Samira Mubareka

  • Sigmund Krajden

  • Larissa Matukas

  • Sharon Walmsley

  • Medina Saffie

  • Daniel Ricciuto

  • Krystyna Ostrowska

  • David Richardson

  • Shannon N Pyra

  • Joslyn D Gray

  • July 7, 2026

  • 0 min

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Objective:

To estimate the incidence of recurrent invasive pneumococcal disease (rIPD) over time and assess risk factors for rIPD at the primary episode.

Approach:
  • Study Design: Cohort study approved by relevant ethics boards, utilizing population-based surveillance data from the Toronto-Peel region and Calgary.
  • Data Collection: Demographic and clinical data collected through medical record review; immunization history obtained from public health databases.
  • Data Analysis: Annual incidence of primary IPD and rIPD calculated; statistical comparisons made using logistic regression and Cox proportional hazards regression.
Key Findings:
  • Recurrent IPD reported in 2.2% to 5.3% of individuals with IPD.
  • Incidence of rIPD estimated to be 27 times that of primary IPD.
  • Immunocompromising conditions identified as risk factors for rIPD.
Interpretation:

Limitations:
  • Data on all-cause mortality and out-migration were not accessible.
  • Study focused on specific regions, which may limit generalizability.
Conclusion:

Original Source(s)

Incidence of Recurrent Invasive Pneumococcal Disease in Canada

  • by Leah J. Ricketson, Altynay Shigayeva, Irina Rajakumar, Zoe Zhong, Kazi Hassan, Irene Martin, Alyssa Golden, Allison J. McGeer, James D. Kellner, Calgary Area Epidemiology Research Group and the Toronto Invasive Bacterial Diseases Network, Chingiz Amirov, Neil Rau, Danny Chen, Jeff Powis, Amna Faheem, Kevin Katz, Valerie Sales, Samir Patel, Abdelbaset Belhaj, Reena Lovinsky, David Rose, Christie Vermeiren, Tony Mazzulli, Jennie Johnstone, Karen Green, Michael Lingley, Andrew Simor, Samira Mubareka, Sigmund Krajden, Larissa Matukas, Sharon Walmsley, Medina Saffie, Daniel Ricciuto, Krystyna Ostrowska, David Richardson, Shannon N Pyra, Joslyn D Gray

  • July 7, 2026

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