To evaluate long-term neurodevelopmental trajectories in neonates with hyperbilirubinemia and develop a predictive model integrating biomarkers and neurobehavioral assessments for neurodevelopmental impairment at one year of age.
Key Findings:
12.8% of infants exhibited neurodevelopmental impairment at 12 months.
Elevated C-reactive protein (CRP), higher bilirubin-to-albumin ratio (B/A), and increased neuron-specific enolase (NSE) were identified as independent risk factors.
Higher NBNA scores were associated with a protective effect against neurodevelopmental impairment.
The model demonstrated an apparent AUC of 0.813 and an optimism-corrected AUC of 0.797.
Interpretation:
The developed model aids in risk stratification for follow-up based on the findings of the study.
Limitations:
The study focused only on term neonates, limiting generalizability to preterm infants.
Follow-up duration was limited to one year, which may not capture all neurodevelopmental outcomes.
Conclusion:
The predictive model supports monitoring for high-risk infants with hyperbilirubinemia based on the study's findings.
